Professor Tao Ren, Ph.D.

High Magnetic Field Laboratory, Chinese Academy of Sciences 350 Shushanhu Road, Building 2, Room 413 Hefei, Anhui, P. R. China 230031

Phone: +86-551-65591485
E-mail: rent@hfcas.ac.cn

Tao Ren, Ph.D., Professor. Graduated from Shandong University with BS/MS degree, Graduate study in University of Nebraska-Lincoln, USA from 1999-2003, finished with a Ph.D. in Molecular Biology, Post-doctoral research in Genetics, Harvard Medical School from 2003 to 2007. Since 2007, he has been working at ICCB, HMS as a senior scientist. Joined the High Magnetic Field Laboratory of the Chinese Academy of Sciences in 2016 as a professor. Main expertise includes HTS, new drug discovery and target identification. Multiple publications since 1999 in international SCI journals, including Plant Cell, J. Virology, Nature, and PLoS Pathogen, etc.  
 
 
 
 
 

PUBLICATIONS

  1. “Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutants Kinase Inhibitor with a Distinct Binding Mode.” Aoli Wang#, Xixiang Li#, Hong Wu#, Fengming Zou#, Xiao-E Yan#, Cheng Chen, Chen Hu, Kailin Yu, Wenchao Wang, Peng Zhao, Jiaxin Wu, Ziping Qi, Wei Wang, Beilei Wang, Li Wang, Tao Ren, Shanchun Zhang, Cai-Hong Yun*, Jing Liu*, and Qingsong Liu*. J. Med. Chem. 2017, DOI: 10.1021/acs.jmedchem.6b01907.
  2. “Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.” Qianmao Liang, Yongfei Chen, Kailin Yu, Cheng Chen, Shouxiang Zhang, Aoli Wang, Wei Wang, Hong Wu, Xiaochuan Liu, Beilei Wang, Li Wang, Zhenquan Hu, Wenchao Wang, Tao Ren, Shanchun Zhang, Qingsong Liu, Cai-Hong Yun*, Jing Liu*. Eur. J. Med.Chem. 2017, DOI: 10.1016/j.ejmech.2017.03.001.
  3. “Discovery of 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor.” Xiaofei Liang, Fengchao Lv, Beilei Wang, Kailin Yu, Hong Wu, Ziping Qi, Zongru Jiang, Cheng Chen, Aoli Wang, Weili Miao, Wenchao Wang, Zhenquan Hu, Juan Liu, Xiaochuan Liu, Zheng Zhao, Li Wang, Shanchun Zhang, Zi Ye, Chu Wang, Tao Ren, Yinsheng Wang, Qingsong Liu*, and Jing Liu*. J. Med. Chem. 2017, DOI: 10.1021/acs.jmedchem.6b01413.
  4. “Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding.” Qiang Wang, Feiyang Liu, Beilei Wang, Fengming Zou, Ziping Qi, Cheng Chen, Kailin Yu, Chen Hu, Shuang Qi, Wenchao Wang, Zhenquan Hu, Juan Liu, Wei Wang, Li Wang, Qianmao Liang, Shanchun Zhang, Tao Ren, Qingsong Liu*,Jing Liu*. J. Med. Chem. 2016, DOI: 10.1021/acs.jmedchem.6b01290.
  5. “Discovery of N-((1-(4-(3-(3-((6,7-dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase.” Binhua Li, Aoli Wang, Juan Liu, Ziping Qi, Xiaochuan Liu, Kailin Yu, Hong Wu, Cheng Chen, Chen Hu, Wenchao Wang, Jiaxin Wu, Zhenquan Hu, Ling Ye, Fengming Zou, Feiyang Liu, Beilei Wang, Li Wang, Tao Ren, Shaojuan Zhang, Mingfeng Bai, Shanchun Zhang, Jing Liu*, Qingsong Liu*. J. Med. Chem. 2016, DOI: 10.1021/acs.jmedchem.6b00902.
  6. Weisberg E, Halilovic E, Cooke VG, Nonami A, Ren T, Sanda T, Simkin I, Yuan J, Antonakos B, Barys L, Ito M, Stone R, Galinsky I, Cowens K, Nelson E, Sattler M, Jeay S, Wuerthner JU, McDonough SM, Wiesmann M, Griffin JD. Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097. Mol. Cancer Ther. 2015, 14(10): 2249-59.
  7. Kyungae Lee, Tao Ren, John Misasi, and James Cunningham. Inhibitors of Ebola virus infection: Hit-to-lead optimization and identification of host cell Niemann-Pick C1 as the molecular target. ACS Med. Chem. Lett. 2013, 4: 239−243.
  8. Qingsong Liu#, Tao Ren#, Tara Fresques, Wolfgang Oppliger, Brad J. Niles, Wooyoung Hur, David Sabatini, Michael N. Hall, Ted Powers, and Nathanael S. Gray*. Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae. ACS Chem. Biol. 2012, 7(6): 982–987.
  9. Marceline Côté#, John Misasi#, Tao Ren#, Anna Bruchez#, Kyungae Lee, Claire Marie Filone, Lisa Hensley, Qi Li, Daniel Ory, Kartik Chandran, and James Cunningham. Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection. Nature 2011, 477(7364): 344-348.
  10. Karen L. Stirrett, Julian A. Ferreras, Barij N. Sinha, Jayaprakash Venkatesan, Tao Ren, and Luis E.N. Quadri. Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Bioorg. Med. Chem. Lett. 2008, 18(8): 2662-2668.
  11. Tao Ren, Dario S. Zamboni, Craig R. Roy, William F. Dietrich, and Russell E. Vance. Flagellin-deficient Legionella mutants evade caspase-1 and Naip-5-mediated macrophage immunity. PLoS Pathog. 2006, 2(3): e18.
  12. Tao Ren, Feng Qu, and T. Jack Morris. The nuclear localization of the Arabidopsis transcription factor TIP is blocked by its interaction with the coat protein of Turnip crinkle virus. Virology 2005, 331(2): 316-324.
  13. Chang Wan Choi, Feng Qu, Tao Ren, Xiaohong Ye,  and T. Jack Morris. The RNA silencing suppressor function of Turnip crinkle virus coat protein cannot be attributed to its interaction with the Arabidopsis protein TIP. J Gen. Virol. 2004, 85(11): 3415-3420.
  14. Feng Qu, Tao Ren, and T. Jack Morris. The coat protein of Turnip crinkle virus suppresses post-transcriptional gene silencing at an early initiation step. J. Virol. 2003, 77(1): 511-522.
  15. Tao Ren, Feng Qu, and T Jack Morris. HRT gene function requires interaction between a NAC protein and viral capsid protein to confer resistance to Turnip crinkle virus. Plant Cell 2000, 12(10): 1917-1925.