FengmingZou
Associate Professor


High magnetic field of Laboratory
E-mail: fmzou@hmfl.ac.cn

Phone: +86-13866130265 

 

Personal History

Education

Ph. D

Sep. 2010-Aug. 2013

Department of Applied Biology, Dong-A University, South Korea
Advisor: Prof. Byungrae Jin
Thesis topic at “Molecular characterization of CuticularMelanization in the Silkworm, Bombyxmori”

Master

Sep. 2007-Jun. 2010

School of Biological and Environmental Engineering, Jiangsu University of Science and Technology, Republic of China
Advisor: Prof. Zhongzheng Gui

Bachelor

Sep. 2003-Jun. 2007

Department of Environmental and Biological Engineering, Chongqing Technology and Business University, Republic of China
Advisor: Prof. Jianhui Liu

Research Career

03/2015 - Present

Assistant Professor, High magnetic field of Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China;

09/2013– 02/2015

Post-Doc., Department of Nano Fusion Technologyand BK21 Plus Nano Convergence Technology Division, Pusan National University, Busan, South Korea supported by the " BK21 plus+ grand of Korea GovernmentProgram of Pusan National University"

Currently Research Area

  • Applications of nanomaterial in biomedical field, such as nanoparticles cytotoxicity in vivo and in vitro, biosensor etc.
  • Graphene-based nanocomposites antibacterial effect depend on surface roughness
  • Hyperthermia for cancer treatment using Multi-functional Nanoparticles

Awards/Scholarship

2010-2013

Tuition, stipend and travel fee are fully supported by Brain Korea 21 Scholarship.

2010

The Excellent Postgraduate Student (JiangsuUniversity of Science and Technology)

2007

The Excellent Undergraduate Student (Chongqing Technology and Business University)

Publication list

  1. Fengming Zou#, Hongjian Zhou#, Do Young Jeong, Junyoung Kwon, Seong Un Eom, Tae Jung Park, Suck Won Hong*, and Jaebeom Lee*. Wrinkled Surface-Mediated Antibacterial Activity of Graphene Oxide Nanosheets. ACS Appl. Mater. Interfaces, DOI: 10.1021/acsami.6b15085.
  2. Qiang Wang#, Feiyang Liu#, Beilei Wang#, Fengming Zou#, Ziping Qi, Cheng Chen, Kailin Yu, Chen Hu, Shuang Qi, Wenchao Wang, Zhenquan Hu, Juan Liu, Wei Wang, Li Wang, Qianmao Liang, Shanchun Zhang, Tao Ren, Qingsong Liu*, Jing Liu*. Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. J. Med. Chem. 2016, DOI: 10.1021/acs.jmedchem.6b01290.
  3. Xiaochuan Liu#, Aoli Wang#, Xiaofei Liang#, Juanjuan Liu#, Fengming Zou#, Cheng Chen, Zheng Zhao, Yuanxin Deng, Hong Wu, Ziping Qi, Beilei Wan, Li Wang, Feiyang Liu, Yunhe Xu, Wenchao Wang, Stacey M. Fernandes, Richard M. Stone, Ilene A. Galinsky, Jennifer R. Brown, Teckpeng Loh, James. D. Griffin, Shanchun Zhang, Ellen L. Weisberg*, Xin Zhang*, Jing Liu*, Qingsong Liu*. Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies. Oncotarget 2016. DOI: 10.18632/oncotarget.10650.
  4. Qiang Wang#, Feiyang Liu#, Beilei Wang#, Fengming Zou#, Cheng Chen, Xiaochuan Liu, Aoli Wang, Shuang Qi, Wenchao Wang, Ziping Qi, Zheng Zhao, Zhenquan Hu, Wei Wang, Wang Li, Shanchun Zhang, Yuexiang Wang, Jing Liu*, and Qingsong Liu*. Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). J. Med. Chem. 2016. DOI: 10.1021/acs.jmedchem.6b00200.
  5. Xiaofei Liang#, Xiaochuan Liu#, Beilei Wang#, Fengming Zou#, Aoli Wang, Shuang Qi, Cheng Chen, Zheng Zhao, Wenchao Wang, Ziping Qi, Fengchao Lv, Zhenquan Hu, Li Wang, Shanchun Zhang, Qingsong Liu*, and Jing Liu*. Discovery of 2-((3-amino-4-methylphenyl)amino)-N-(2-methyl-5-(3- (trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a potent, selective and orally available BCR-ABL/SRC/p38 kinase inhibitor for Chronic Myeloid Leukemia, J. Med. Chem., DOI: 10.1021/acs.jmedchem.5b01618, 2016.
  6. Fengming Zou#, Hongjian Zhou, Van Tan Tran, Jeonghyo Kim, Kwangnak Koh, Jaebeom Lee*. Dual-mode SERS-Fluorescence Immunoassay using Graphene Quantum Dot Labeling on 1D-aligned Magnetoplasmonic Nanoparticles, ACS applied materials & interfaces 2015, 7 (22): 12168–12175.
  7. Fengming Zou#, Kwang Sik Lee, Bo Yeon Kim, Hong Ja Kim, Zhong Zheng Gui, Guo Zheng Zhang, Xijie Guo, Byung Rae Jin*. Differential and spatial regulation of the prophenoloxidase (proPO) and proPO-activating enzyme in cuticular melanization and innate immunity in Bombyx mori pupae, Journal of Asia-Pacific Entomology 2015, 18(4): 757-764.
  8. Fengming Zou#, Qianqian Ding, Van Tan Tran, Guozhong Wang, Yunxia Zhang, Shenghong Kang, Jaebeom Lee*and  Hongjian Zhou*. Magnetically Recyclable Catalytic Activity of Spiky Magnetoplasmonic Nanoparticles, RSC Advances 2015, 5: 56653-56657.
  9. Fengming Zou#, Kwangsik Lee, Hu Wan, Zhongzheng Gui, Byung Rae Jin*. Morphological abnormalities and lethality in silkworm (Bombyxmori) larvae treated with high concentrations of insect growth-blocking peptide, Journal of Asia-Pacific Entomology 2014, 17(1): 93-97.
  10. Fengming Zou#, De-Shuai Lou, Ya-Hong Zhu, Sheng-Peng Wang, Byung-Rae Jin, Zhong-ZhengGui*. Expression profiles of glutathione S-transferase genes in larval midgut of Bombyxmori exposed to insect hormones, Molecular biology reports 2011, 639-647.
    11. Co-author:
  11. Binhua Li#, Aoli Wang#, Juan Liu#, Ziping Qi#, Xiaochuan Liu, Kailin Yu, Hong Wu, Cheng Chen, Chen Hu, Wenchao Wang, Jiaxin Wu, Zhenquan Hu, Ling Ye, Fengming Zou, Feiyang Liu, Beilei Wang, Li Wang, Tao Ren, Shaojuan Zhang, Mingfeng Bai, Shanchun Zhang, Jing Liu*, Qingsong Liu*. Discovery of N-((1-(4-(3-(3-((6,7-dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase. J. Med. Chem. 2016, DOI: 10.1021/acs.jmedchem.6b00902.
  12. Feiyang Liu#, Beilei Wang#, Qiang Wang#, Ziping Qi#, Cheng Chen, Lu-Lu Kong, Ji-Yun Chen, Xiaochuan Liu, Aoli Wang, Chen Hu, Wenchao Wang, Huiping Wang, Fan Wu, Yanjie Ruan, Shuang Qi, Juan Liu, Fengming Zou, Zhenquan Hu, Wei Wang, Li Wang, Shanchun Zhang, Cai-Hong Yun, Zhimin Zhai, Jing Liu*, Qingsong Liu*. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget 2016, Jun 14.DOI: 10.18632/oncotarget.10037.
  13. Hong Wu#, Aoli Wang#, Ziping Qi#, Xixiang Li#, Cheng Chen#, Kailin Yu, Fengming Zou, Chen Hu, Wenchao Wang, Zheng Zhao, Jiaxin Wu, Juan Liu, Xiaochuan liu, Li Wang, Wei Wang, Shanchun Zhang, Richard M. Stone, Ilene A. Galinsky, James D. Griffin, David Weinstock, Alexandra Christodoulou, Huiping Wang, Yuanyuan Shen, Zhimin Zhai*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML. Leukemia 2016, DOI: 10.1038/leu.2016.151.
  14. Aoli Wang#, Hong Wu#, Cheng Chen#, Chen Hu#, Ziping Qi#, Wenchao Wang, Kailin Yu, Xiaochuan Liu, Fengming Zou, Zheng Zhao, Jiaxin Wu, Juan Liu, Feiyang Liu, Wang Li, Richard M. Stone, Ilene A. Galinksy, James D. Griffin4, Shanchun Zhang, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu *. Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML. Oncotarget. 2016. DOI: 10.18632/oncotarget.8675.
  15. Xixiang Li#, Aoli Wang#, Kailin Yu#, Ziping Qi#, Cheng Chen, Wenchao Wang, Chen Hu, Hong Wu, Jiaxin Wu, Zheng Zhao, Juan Liu, Fengming Zou, Li Wang, Beilei Wang, Wei Wang, Shanchun Zhang, Jing Liu*, Liu Qingsong*. Discovery of (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. J. Med. Chem. 2015, DOI:10.1021/acs.jmedchem.5b01611.
  16. Hongjian Zhou#, Fengming Zou, Van Tan Tran and Jaebeom Lee*. Simultaneous enhancement of Raman scattering and fluorescence emission on graphene quantum dot-spiky magnetoplasmonic supra-particle composite films, RSC Advances 2015, 5, 81753-81758.
  17. H Wu#, C Hu#, A Wang#, E L Weisberg#, Y Chen, C-H Yun, W Wang, Y Liu, X Liu, B Tian, J Wang, Z Zhao, Y Liang, B Li, L Wang, B Wang, C Chen, S J Buhrlage, Z Qi, F Zou, A Nonami, Y Li, S M Fernandes, S Adamia, R M Stone, I A Galinsky, X Wang, G Yang, J D Griffin, J R Brown, M J Eck, J Liu*, N S Gray* and Q Liu*, Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia, Leukemia (13 July 2015) doi:10.1038/leu.2015.180.
  18. Hongjian Zhou#, Sun Il Choi#, Fengming Zou, Sangjin Oh, Ji Eun Kim, Dae Youn Hwang, Jaebeom Lee*, Cytotoxicity and gene expression in sarcoma 180 cells in response to the spiky magnetoplasmonic nanoparticles, ACS Applied Materials & Interfaces 2014, 6, 19680-19689.
  19. Hongjian Zhou#, Fengming Zou, Kwangnak Koh, Jaebeom Lee*, Multifunctional Magnetoplasmonic Nanomaterials and Their Biomedical Application, Journal of Biomedical Nanotechnology 2014, 10, 2921-2949.
  20. Hongjian Zhou#, Jeonghyo Kim, FengmingZou, KwangnakKoh, Jung Youn Park, Jaebeom Lee*, Rapid Detection of DNA by Magnetophoretic Assay, Sensors and Actuators B: Chemical. 2014, 198, 77-81.
  21. Van Tan Tran#, Hongjian Zhou, Seungjun Kim, Jaewook Lee, Jeonghyo Kim, Fengming Zou, Jongman Kim, Jung Youn Park, Jaebeom Lee*, Self-assembled Magentoplasmonic Nanochain for DNA sensing, Sensors and Actuators B: Chemical. 2014, 203, 817-823.
  22. DongWan Kang#, Fangfang Sun, Yoon Ji Choi, Fengming Zou, WonHo Cho, ByungKwan Choi, Kwangnak Koh, Jaebeom Lee*, In Ho Han*. Enhancement of primary neuronal cell proliferation using printing-transferred carbon nanotube sheets, Accepted by Journal of Biomedical Materials Research Part A 2014. DOI: 10.1002/jbm.a.35294.
  23. Jie Yu#, Feng-Yao Wu, Fengming Zou, Xiang-Yun Cai, Hai-Yan Yu, Yan-Wei Liu, Yin Fang, Zi-XuRen, Jun-QiangJia, Guo-Zheng Zhang, Xi-JieGuo, Byung-Rae Jin, Zhong-ZhengGui*. Identification and functional analysis of the cathepsin D gene promoter of Bombyxmori, Molecular biology reports 2014, 41(3): 1623-1630.
  24. Hu Wan#, KwangSik Lee, Bo Yeon Kim, Fengming Zou, HyungJoo Yoon, YeonHo Je, Jianhong Li, Byung Rae Jin*. A Spider-Derived Kunitz-Type Serine Protease Inhibitor That Acts as a Plasmin Inhibitor and an Elastase Inhibitor, Plos One 2013, 8(1).
  25. Bo Yeon Kim#, KwangSik Lee, Hu Wan, Fengming Zou, Yong Soo Choi, HyungJoo Yoon, HyungWook Kwon, YeonHo Je, Byung Rae Jin*. Anti-elastolytic activity of a honeybee (Apiscerana) chymotrypsin inhibitor, Biochemical and Biophysical Research Communications 2013, 430(1): 144-149.
  26. Jie Yu#, Feng-Yao Wu, Fengming Zou, Jun-QiangJia, Sheng-Peng Wang, Guo-Zheng Zhang, Xi-JieGuo, Zhong-ZhengGui*. Identification of Ecdysone Response Elements (EcREs) in the BombyxmoriCathepsinDPromoter , Biochemical and Biophysical Research Communications 2012, 425(1): 113-118.
  27. Feng Yao Wu#, Fengming Zou, Jun Qiang Jia, Sheng Peng Wang, Guo Zheng Zhang ,Xi Jie Guo, Zhong Zheng Gui*. The Influence of Challenge on Cathepsin B and D Expression Patterns in the Silkworm Bombyxmori L, International Journal of Industrial Entomology 2011, 23(1): 129-135.
  28. De-ShuaiLou#, Fengming Zou, Hui Yan and Zhong-Zheng Gui*. Factors influencing the biosynthesis of 1-deoxynojirimycin in Morus Alba L, African Journal of Agricultural Research 2011, 6(13): 2998-3006.