Kailin Yu

PhD student

350 Shushanhu Road, Hefei, Anhui, 230031, P.R. China

Tel:+86-551-65595117

E-mail: shiqinianchan1@163.com

 

Education Background

2009/09 – 2013/06,Hunan Nomal university,bachelor

2013/09 -till now,High Magnetic Field Laboratory of Chinese Academy of Sciences, Ph.D Student

 

 

Publications/Patent

  1. Qianmao Liang#, Yongfei Chen#, Kailin Yu#, Cheng Chen, Shouxiang Zhang, Aoli Wang, Wei Wang, Hong Wu, Xiaochuan Liu, Beilei Wang, Li Wang, Zhenquan Hu, Wenchao Wang, Tao Ren, Shanchun Zhang, Qingsong Liu, Cai-Hong Yun*, Jing Liu*. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur. J. Med. Chem. 2017, DOI:10.1016/j.ejmech.2017.03.001.
  2. Xiaofei Liang#, Fengchao Lv#, Beilei Wang#,Kailin Yu#, Hong Wu, Ziping Qi, Zongru Jiang, Cheng Chen, Aoli Wang, Weili Miao, Wenchao Wang, Zhenquan Hu, Juan Liu, Xiaochuan Liu, Zheng Zhao, Li Wang, Shanchun Zhang, Zi Ye, Chu Wang, Tao Ren, Yinsheng Wang, Qingsong Liu*,and Jing Liu*.Discovery of 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J. Med. Chem. 2017, 60(5): 1793-1816.
  3. Xixiang Li#, Aoli Wang#, Kailin Yu#, Ziping Qi, Cheng Chen, Wenchao Wang, Chen Hu, Hong Wu, Jiaxin Wu, Zheng Zhao, Juan Liu, Fengming Zou, Li Wang, Beilei Wang, Wei Wang, Shanchun Zhang, Jing Liu*,Liu Qingsong*.Discovery of (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. J. Med. Chem. 2015, 58(24): 9625-38.
  4. Binhua Li#, Aoli Wang#, Juan Liu#, Ziping Qi#, Xiaochuan#, Kailin Yu, Hong Wu, Cheng Chen, Chen Hu, Wenchao Wang, Jiaxin Wu, Zhenquan Hu, Ling Ye, Fengming Zou, Feiyang Liu, Beilei Wang, Li Wang, Tao Ren, Shaojuan Zhang, Mingfeng Bai, Qingsong Liu*, Jing Liu*, Discovery of CHMFL-KIT-8140 as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I “Gatekeeper” Mutant of c-KIT Kinase. J. Med. Chem. 2016, 59(18): 8456-72.
  5. Feiyang Liu#, Wang J#, Xingxing Yang#, Binhua Li#, Hong Wu, Shuang Qi, Cheng Chen, Xiaochuan Liu,kailin Yu, Wenchao Wang, Zhao, Aoli Wang, Yongfei Chen, Li Wang, Nathanael S Gray*, Jing Liu*, Xin Zhang*, Qingsong Liu*. Discovery of a Highly Selective STK16 Kinase Inhibitor. ACS Chem. Biol. 2016, 11(6): 1537-43.
  6. Hong Wu#, Aoli Wang#, Ziping Qi#, Xixiang Li#, Cheng Chen, Kailin Yu, Fengming Zou, Chen Hu, Wenchao Wang, Zheng Zhao, Jiaxin Wu, Juan Liu, Xiaochuan Liu, Li Wang, Wei Wang, Shanchun Zhang, Richard M. Stone, Ilene A. Galinsky, James D. Griffin, David Weinstock, Alexandra Christodoulou, Huiping Wang, Yuanyuan Shen, Zhimin Zhai*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML. Leukemia 2016, 30(10): 2112-2116.
  7. Aoli Wang#, Hong Wu#, Cheng Chen#, Chen Hu#, Ziping Qi#, Wenchao Wang, Kailin Yu, Xiaochuan Liu, Fengming Zou, Zheng Zhao, Jiaxin Wu, Juan Liu, Feiyang Liu, Wang Li, Richard M. Stone, Ilene A. Galinksy, James D. Griffin4, Shanchun Zhang, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML. Oncotarget 2016, 7(20): 29131-42.
  8. 发明名称：A674563在携带FLT3突变型基因的急性白血病中的新用途. 发明人：刘青松， 刘静， 王傲莉，吴宏，陈程，胡晨，王文超，刘晓川，余凯琳，赵铮，吴佳昕，刘娟，王黎，王蓓蕾.
  9. 发明名称：FLT3激酶的新型抑制剂及其用途. 发明人：刘静，刘青松，李希祥，王傲莉，吴宏，陈程，王文超，胡晨，赵铮，吴佳昕，刘娟，余凯琳，王伟，王黎，王蓓蕾.