PUBLICATIONS

1. Binhua Li#, Aoli Wang#, Juan Liu#, Ziping Qi#, Xiaochuan Liu#, Kailin Yu, Hong Wu, Cheng Chen, Chen Hu, Wenchao Wang, Jiaxin Wu, Zhenquan Hu, Ling Ye, Fengming Zou, Feiyang Liu, Beilei Wang, Li Wang, Tao Ren, Shaojuan Zhang, Mingfeng Bai, Qingsong Liu*, Jing Liu*, Discovery of CHMFL-KIT-8140 as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I “Gatekeeper” Mutant of c-KIT Kinase. J. Med. Chem. 2016, 59(18):8456-72. doi: 10.1021/acs.jmedchem.6b00902.
2. Hong Wu#, Aoli Wang#, Ziping Qi#, Xixiang Li#, Cheng Chen#, Kailin Yu, Fengming Zou, Chen Hu, Wenchao Wang, Zheng Zhao, Jiaxin Wu, Juan Liu, Xiaochuan liu, Li Wang, Wei Wang, Shanchun Zhang, Richard M. Stone, Ilene A. Galinsky, James D. Griffin, David Weinstock, Alexandra Christodoulou, Huiping Wang, Yuanyuan Shen, Zhimin Zhai*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*, Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML, Leukemia 2016, 30(10):2112-2116. doi:10.1038/leu.2016.151.
3. Xiaochuan Liu#, Aoli Wang#, Xiaofei Liang#, Cheng Chen#, Juanjuan Liu, Zheng Zhao, Hong Wu, Yuanxin Deng, Wang Li,, Beilei Wang, Jiaxin Wu, Feiyang Liu, Stacey M. Fernandes, Sophia Adamia, Richard M. Stone, Ilene A. Galinsky, Jennifer R. Brown, James D. Griffin, Shanchun Zhang, Teckpeng Loh, Xin Zhang, Wenchao Wang*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances. Oncotarget 2016, 7(22):32641-51. doi: 10.18632/oncotarget.8702.
4. Aoli Wang#, Hong Wu#, Cheng Chen#, Chen Hu#, Ziping Qi#, Wenchao Wang, Kailin Yu, Xiaochuan Liu#, Fengming Zou, Zheng Zhao, Jiaxin Wu, Juan Liu, Feiyang Liu, Wang Li, Richard M. Stone, Ilene A. Galinksy, James D. Griffin4, Shanchun Zhang, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML. Oncotarget 2016, 7(20):29131-42. doi: 10.18632/oncotarget.8675.
5. Xixiang Li#, Aoli Wang#, Kailin Yu#, Ziping Qi#, Cheng Chen, Wenchao Wang, Chen Hu, Hong Wu, Jiaxin Wu, Zheng Zhao, Juan Liu, Fengming Zou, Li Wang, Beilei Wang, Wei Wang, Shanchun Zhang, Jing Liu*,Liu Qingsong*, Discovery of (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia, J. Med. Chem. 2015, 58(24):9625-38. doi: 10.1021/acs.jmedchem.5b01611.
6. Hong Wu#, Aoli Wang#, Wei Zhang#, Beilei Wang#, Cheng Chen#,Wenchao Wang, Chen Hu, Zi Ye, Zheng Zhao, Li Wang, Xixiang Li, Kailin Yu,Juan Liu, Jiaxin Wu, Xiao-E Yan, Peng Zhao, Jinhua Wang, Chu Wang,Ellen L. Weisberg, Nathanael S. Gray, Cai-Hong Yun, Jing Liu*, Liang Chen*,Liu Qingsong*, Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells, Oncotarget 2015, 6(31):31313-22. doi: 10.18632/oncotarget.5182
7. Wu Hong#, Hu Chen#, Wang Aoli#, E L Weisberg#, Wang Wenchao, Chen Cheng, Zhao Zheng, Yu Kailin, Liu Juan, Wu Jiaxin, A Nonami, Wang Li, Wang Beilei, R M Stone, S Liu, J D Griffin,Liu Jing* and Liu Qingsong*, Ibrutinib selectively targets FLT3-ITD in mutant FLT3-positive AML, Leukemia 2015, 6(31):31313-22. doi:10.1038/leu.2015.175.

PATENTS

1: "FLT3 kinase new inhibitors and its application!",  Liu, Qingsong; Liu Jing;Li Xixiang;Wang Aoli; Wu Hong; Chen Cheng;Wang Wenchao; Hu Chen; Zhao Zheng; Wu Jiaxin; Liu Juan;Yu Kailin; Wang Wei; Wang Li; Wang Beilei. (2015)
2: "A674563 is sensitive to FLT3-ITD dependent AML !",  Liu, Qingsong; Liu Jing;Wang Aoli; Wu Hong; Chen Cheng; Hu Chen; Wang Wenchao; Liu Xiaochuan; Yu Kailin; Zhao Zheng; Wu Jiaxin; Liu Juan; Wang Li; Wang Beilei. (2015)

已申请中国专利：
1. 发明名称：FLT3激酶的新型抑制剂及其用途
发明人：刘青松，刘静，李希祥，王傲莉，齐紫平，吴宏，吴佳昕，王文超，胡晨，陈程， 王黎，王蓓蕾
专利受理号：201610409235.5
2. 发明名称：一种新型 EGFR 和 ALK 激酶的双重抑制剂
发明人： 刘静， 刘青松， 江桃山，王傲莉， 吴佳昕，吴宏，齐紫平，陈永飞，邹凤鸣，王文超，赵铮，王黎，王蓓蕾
专利受理号：201510946305.6
3. 发明名称：FLT3激酶的新型抑制剂及其用途
发明人：刘青松，刘静，李希祥，王傲莉，吴宏，陈程，王文超，胡晨，赵铮，吴佳昕，刘娟，余凯琳，王伟，王黎，王蓓蕾
专利受理号：201510547224.9
4. 发明名称：A674563在携带FLT3突变型基因的急性白血病中的新用途
发明人：刘青松， 刘静， 王傲莉，吴宏，陈程，胡晨，王文超，刘晓川，余凯琳，赵铮，吴佳昕，刘娟，王黎，王蓓蕾
专利受理号：201510262944.0
5. 发明名称：FLT3激酶的新型抑制剂及其用途
发明人：刘静，刘青松，李希祥，王傲莉，吴宏，陈程，王文超，胡晨，赵铮，吴佳昕，刘娟，余凯琳，王伟，王黎，王蓓蕾