Xiaochuan Liu

PostDoc

Tel: 65595117

E-mail:981695727@qq.com

Work Experience

2016/07-now, PostDoc, High Magnetic Field Laboratory, CAS. Advisor: Prof. Wenchao Wang

Education

2011/09-2016/06, High Magnetic Field Laboratory, CAS, Chemical Biology, Ph.D.
Advisor: Prof. Duoping Luo, Prof. Qingsong Liu

2007/09-2011/06, Chuzhou university, Biology, Bachelor

 

Publications

  1. Binhua Li#, Aoli Wang#, Juan Liu#, Ziping Qi#, Xiaochuan Liu#, Kailin Yu, Hong Wu, Cheng Chen, Chen Hu, Wenchao Wang, Jiaxin Wu, Zhenquan Hu, Ling Ye, Fengming Zou, Feiyang Liu, Beilei Wang, Li Wang, Tao Ren, Shaojuan Zhang, Mingfeng Bai, Qingsong Liu*, Jing Liu*, Discovery of CHMFL-KIT-8140 as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I “Gatekeeper” Mutant of c-KIT Kinase. J. Med. Chem. 2016, 59(18): 8456-72. doi: 10.1021/acs.jmedchem.6b00902.
  2. Xiaochuan Liu#, Aoli Wang#, Xiaofei Liang#, Juanjuan Liu#, Fengming Zou#, Cheng Chen#, Zheng Zhao, Yuanxin Deng, Hong Wu, Ziping Qi,Beilei Wang, Li Wang, Feiyang Liu, Yunhe Xu, Wenchao Wang, Stacey M.Fernandes, Richard M. Stone, Ilene A. Galinsky, Jennifer R. Brown, Teckpeng Loh, James. D. Griffin, Shanchun Zhang, Ellen L. Weisberg*, Xin Zhang*, Jing Liu*, Qingsong Liu*. Simultaneous inhibition of Vps34 kinase would enhance PI3Kδinhibitor cytotoxicity in the B-cell malignancies. Oncotarget 2016, 7(33): 53515-53525. doi: 10.18632/oncotarget.10650.
  3. Xiaochuan Liu#, Aoli Wang#, Xiaofei Liang#, Cheng Chen#, Juanjuan Liu, Zheng Zhao, Hong Wu, Yuanxin Deng, Wang Li,, Beilei Wang, Jiaxin Wu, Feiyang Liu, Stacey M. Fernandes, Sophia Adamia, Richard M. Stone, Ilene A. Galinsky, Jennifer R. Brown, James D. Griffin, Shanchun Zhang, Teckpeng Loh, Xin Zhang, Wenchao Wang*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances. Oncotarget 2016, 7(22): 32641-51. doi: 10.18632/oncotarget.8702.
  4. Xiaofei Liang#, Xiaochuan Liu#, Beilei Wang#, Fengming Zou#, Aoli Wang, Shuang Qi, Cheng Chen, Zheng Zhao, Wenchao Wang, Ziping Qi, Fengchao Lv, Zhenquan Hu, Li Wang, Shanchun Zhang, Qingsong Liu*, and Jing Liu*. Discovery of CHMFL-ABL-053 as a potent, selective and orally available BCR-ABL/SRC/p38 kinase inhibitor for Chronic Myeloid Leukemia. J. Med. Chem. 2016, 59(5): 1984-2004. doi: 10.1021/acs.jmedchem.5b01618.
  5. Feiyang Liu#, Beilie Wang#, Qiang Wang#, Ziping Qi#, Cheng Chen, Lu-Lu Kong, Ji-Yun Chen, Xiaochuan Liu, Aoli Wang, Chen Hu, Wenchao Wang, Huiping Wang, Fan Wu, Yanjie Ruan, Shuang Qi, Juan Liu, Fengming Zou, Zhenquan Hu, Wei Wang, Li Wang, Shanchun Zhang, Cai-Hong Yun4, Zhimin Zhai, Jing Liu*, Qingsong Liu*. Discovery and Characterization of a Novel Potent Type II Native and Mutant BCR-ABL Inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget 2016, 7(29): 45562-45574. doi: 10.18632/oncotarget.10037.
  6. Feiyang Liu#, Wang J#, Xingxing Yang#, Binhua Li#, Hong Wu, Shuang Qi, Cheng Chen, Xiaochuan Liu, kailin Yu, Wenchao Wang, Zhao, Aoli Wang, Yongfei Chen, Li Wang, Nathanael S Gray*, Jing Liu*, Xin Zhang*, Qingsong Liu*. Discovery of a Highly Selective STK16 Kinase Inhibitor. ACS Chem Biol 2016, 11(6): 1537-43. doi: 10.1021/acschembio.6b00250. 
  7. Hong Wu#, Aoli Wang#, Ziping Qi#, Xixiang Li#, Cheng Chen, Kailin Yu, Fengming Zou, Chen Hu, Wenchao Wang, Zheng Zhao, Jiaxin Wu, Juan Liu, Xiaochuan Liu, Li Wang, Wei Wang, Shanchun Zhang, Richard M. Stone, Ilene A. Galinsky, James D. Griffin, David Weinstock, Alexandra Christodoulou, Huiping Wang, Yuanyuan Shen, Zhimin Zhai*, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML. Leukemia 2016, 30(10): 2112-2116. doi: 10.1038/leu.2016.151. 
  8. Qiang Wang#, Feiyang Liu#, Beilei Wang#, Fengming Zou#, Cheng Chen, Xiaochuan Liu, Aoli Wang, Shuang Qi, Wenchao Wang, Ziping Qi, Zheng Zhao, Zhenquan Hu, Wei Wang, Wang Li, Shanchun Zhang, Yuexiang Wang, Jing Liu*, Qingsong Liu*. Discovery of CHMFL-KIT-110 as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). J. Med. Chem. 2016 Apr 28; 59(8):3964-79. doi: 10.1021/acs.jmedchem.6b00200.
  9. Aoli Wang#, Hong Wu#, Cheng Chen#, Chen Hu#, Ziping Qi#, Wenchao Wang, Kailin Yu, Xiaochuan Liu, Fengming Zou, Zheng Zhao, Jiaxin Wu, Juan Liu, Feiyang Liu, Wang Li, Richard M. Stone, Ilene A. Galinksy, James D. Griffin4, Shanchun Zhang, Ellen L. Weisberg*, Jing Liu*, Qingsong Liu*. Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML. Oncotarget 2016, 7(20):29131-42. doi: 10.18632/oncotarget.8675.
  10. Hong Wu#, Chen Hu#, Aoli Wang#, Ellen L. Weisberg#, Yongfei Chen#, Cai-Hong Yun, Wenchao Wang, Yan Liu, Xiaochuan Liu, Bei Tian, Jinhua Wang, Zheng Zhao, Yanke Liang, Binhua Li, Li Wang, Beilei Wang, Cheng Chen, Sara J. Buhrlage, Ziping Qi, Fengming Zou, Atsushi Nonami, Yuyang Li, Stacey M. Fernandes, Sophia Adamia, Richard M. Stone, Ilene A. Galinsky, Xianhuo Wang, Guang Yang, James D. Griffin, Jennifer R. Brown, Michael J. Eck, Jing Liu*, Nathanael S. Gray*, Liu Qingsong*. Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia. Leukemia2016, 30(1): 173-81.  doi: 10.1038/leu.2015.180.

Patents

  1. New class of PI3K's kinase inhibitors. Liu, Qingsong; Liu Jing; Zhang Xin; Liang Xiaofei; Liu Xiaochuan; Liu Juanjuan; Chen Cheng; Zhao Zheng; Wang Aoli; Wang Wenchao; Wu Hong; Wang Beilei; Wang Li.(2015) PCT/CN2015/081240.
  2. A674563 is sensitive to FLT3-ITD dependent AML. Liu, Qingsong; Liu Jing; Wang Aoli; Wu Hong; Chen Cheng; Hu Chen; Wang Wenchao; Liu Xiaochuan; Yu Kailin; Zhao Zheng; Wu Jiaxin; Liu Juan; Wang Li; Wang Beilei.(2015) PCT/CN2015/083717.
  3. New class of BCR-ABL's kinase inhibitors. Liu Jing; Liu, Qingsong; Liang Xiaofei; Wang Beilei; Wang Aoli; Liu Xiaochuan; Chen Cheng; Qi Ziping; Wang Wenchao; Zhao Zheng; Wang Li. (2015) PCT/CN2015/081220.