Yongfei Chen

High Magnetic Field Lab, CAS
P.O. Box 1110, 350 Shushanhu Road, Hefei, 230031

Tel: 0551-65595013
Email: Chenyf@hmfl.ac.cn

 

 

EDUCATION BACKGROUND

Ph.D (2005-2010),？ Organic Chemistry,
School of Chemistry and Chemical Engineering , Lanzhou University

M.S. (2002-2005),？ Organic Chemistry,
School of Chemistry and Chemical Engineering , Sun Yat-sen University

B.S. (1998-2002) Chemistry Education, School of Chemistry and Chemical Engineering,  Xinyang Normal University


RESEARCH EXPERIENCE

(2018-present)？ Associate professor
High Magnetic Field Laboratory, CAS, Anhui, Hefei, China
Structure-Based Development of Kinase Inhibitors as Cancer Drug

(2012-2017)？ Assistant professor
High Magnetic Field Laboratory, CAS, Anhui, Hefei, China
Structure-Based Development of Kinase Inhibitors as Cancer Drug

(2010-2012), Postdoctor , Organic Chemistry, School of Chemistry and Chemical Engineering , Nanjing University

 

PUBLICATIONS

  1. H Wu#, C Hu#, A Wang#, EL Weisberg#, Y Chen#, C-H Yun, W Wang, Y Liu, X Liu, B Tian, J Wang, Z Zhao, Y Liang, B Li, L Wang, B Wang, C Chen, SJ Buhrlage, Z Qi, F Zou, A Nonami, Y Li, SM Fernandes, S Adamia, RM Stone, IA Galinsky, X Wang, G Yang, JD Griffin, JR Brown, MJ Eck, J Liu*, NS Gray*, Q Liu, Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia 2016, 30(1): 173-181.
  2. Ellen Weisberg#*, Atsushi Nonami#, Zhao Chen, Erik Nelson, Yongfei Chen, Feiyang Liu, HaeYeon Cho, Jianming Zhang, Martin Sattler,Constantine Mitsiades, Kwok-Kin Wong, Qingsong Liu, Nathanael S. Gray, James D. Griffin*, Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R. Clinical Cancer Research 2014, 20(21): 5483-5495.
  3. Hong Wu#, Wenchao Wang#, Feiyang Liu#, Ellen L. Weisberg, Bei Tian, Yongfei Chen, Binhua Li, Aoli Wang, Beilei Wang, Zheng Zhao, Douglas W. McMillin, Chen Hu, Hong Li, Jinhua Wang, Yanke Liang, Sara J. Buhrlage, Junting Liang, Jing Liu, Guang Yang, Jennifer R. Brown, Steven P. Treon, Constantine S. Mitsiades, James D. Griffin, Qingsong Liu*, Nathanael S. Gray*, Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma, ACS Chem. Biol. 2014, 9(5): 1086-1091.
  4. Chen Yong-Fei, Wang Hai-Fei, Wang Ya, Luo Yong-Chun, Zhu Hai-Liang, Xu Peng-Fei*, Base- and Copper-Catalyzed Intramolecular Cyclization for the Direct Synthesis of Dihydrofurans, Adv. Syn. Cata. 2010, 352(7): 1163-1168.
  5. Chen Yong-Fei, Ni Nanting, Li Minyong, Xu Peng-Fei, Wang Binghe*. Design and Synthesis of New Heterocyclic Bcr-Abl Inhibitors，Hetero. Commun., 2010, 16(2-3): 123-135.

PATENTS

  1. New class of Bruton’s tyrosine kinase inhibitors, Liu Qingsong, Liu Jing, Chen Yongfei, Wu Hong, Wang Aoli, Wang Beilei, Hu Chen, Wang Wenchao, Chen Cheng, PCT/CN2015/081051
  2. New class of Bruton’s tyrosine kinase inhibitors, Liu Qingsong, Liu Jing, Chen Yongfei, Wu Hong, Wang Aoli, Wang Beilei, Hu Chen, Wang Wenchao, Chen Cheng, 201410280931.1